Medtronic InPen
Medtronic Simplera Sync
Summary
The InPen system enhances management with multiple daily injections because it tracks data in real-time and offers personalized dosing recommendations. This system combines the Guardian Connect CGM with smart insulin pens for more time in range.
This is a disposable, all-in-one CGM sensor integrated with Medtronic’s pump systems (e.g., MiniMed 780G). Typical wear time is 6 days, plus a 24-hour “grace period.” No routine fingersticks are required when the device is in closed-loop/SmartGuard mode.
FDA approved for ages 7+ on the back of the upper arm
MARD of ~9%
Components
Controller
Inpen connects to a mobile app and displays dosage information directly on a smart mobile device.
Cartridge
InPen is compatible with Humalog, Novolog, and Fiasp U-100 3.0 mL insulin cartridges.
Sensor
Sensor is inserted underneath the skin, either on the abdomen or arm. InPen is compatible with the Medtronic Guardian Connect sensor (left) or the Dexcom G6 sensor (right).
Sensor
Sensor uses a thin, flexible filament beneath the skin to continuously measure glucose every 5 minutes. Simple, one-step applicator makes insertion fast and easy.
Device Details
Overview
Discreet and modern option for people using multiple daily injections.
Disposable, all-in-one CGM sensor integrated with Medtronic’s pump systems
Affordability and Access
$$$$
Widely covered. InPen is covered by many insurance companies, typically users pay $50-$60 out-of-pocket copays for the one-year device. Prices range from $0- $549. For those without any insurance coverage, the pen's full price is $549.
$$$$
Coverage depends on region and insurance; supplied via DME or specialty pharmacy.
Data Monitoring Options
Yes
Data can be easily shared with a healthcare provider or family members directly through the InPen app.
Yes
Data streams directly to the pump; users and clinicians can view trends and logs via Medtronic’s platforms.
Data View Options
Yes
Data can be viewed on the InPen mobile app with dosage recommendations, glucose readings, and glucose trends.
Yes
Data view directly on your connected pump or smart device.
Duration and Storage
12-month pen 7-day sensor
Sensor lasts for 7 days, insulin pen lasts for up to 12 months with refillable cartridges, transmitter is rechargeable. Sensor can be stored between 36°F - 86°F and pens can be kept at room temperature.
6 Days
Sensors last 6 days, with a 24-hour grace period, and need about 2 hours to warm up. They work between 41°F – 104°F and should be stored between 36°F – 86°F. They are usually shipped in 1–3 month supplies, which is about 5–15 sensors at a time.
Vision / Auditory / Dexterity
NO text to speech
NO vibration alerts
A LOT of dexterity needed
YES text to speech
YES vibration alerts
Multiple sound sources
Moderate dexterity needed
Patient Considerations
Active Lifestyle
Light on body. Pens are easy to use and do not remain attached to the body, sensor is waterproof.
Compact and integrated. Reducing bulk; compatibility with daily activities depends on the adhesive and body movement. Water-resistant up to 8 feet (2.4 m) for 30 minutes.
Avoiding Highs and Lows
Limited customizability. System integrates the Guardian Connect CGM for high or low alerts but requires manual dose adjustment and limits the ability to adjust insulin levels throughout the day.
SmartGuard closed-loop. Pump adjustments use sensor data continuously to reduce highs and lows.
Comfort
Many components. Have to carry InPen and pen needles. CGM is attached to the body and requires more tape than other sensors.
Low profile. No overtape needed and one-hand insertion.
Easy Insulin Dosing
Dosing recommendations. Displays dosing recommendations and reminders for long-acting insulin.
SmartGuard technology. When paired with the MiniMed 780G, it automatically adjusts basal and gives correction boluses based on sensor readings. In manual mode, glucose values can guide dosing decisions, but fingersticks are required for confirmation.
Easy to Use
Simple design. Replaces regular insulin pen. No additional devices to add on.
All-in-one. Eliminates the need for a separate transmitter, simplifying sensor changes (although more frequent due to the 6-day wear).
Fewer Fingersticks
2 daily finger-sticks are needed to calibrate the sensor.
Calibration is optional. Perfect if you like having that choice.
Privacy
Hideable. Pens are portable but visible when in use. Frequent injections are unavoidable. View recommendations and data on a smartphone.
Small and integrated, but visible on the back of the arm. No separate transmitter reduces the number of visible parts. Alerts and alarms can be adjusted for discretion.