Afrezza
Medtronic InPen
Summary
Inhalable regular human insulin. Cartridges come in three doses: 4, 8, and 12-unit doses.
The InPen system enhances management with multiple daily injections because it tracks data in real-time and offers personalized dosing recommendations. This system combines the Guardian Connect CGM with smart insulin pens for more time in range.
Components
Inhaler
Small refillable inhaler contains a compartment for powdered insulin containing cartridges.
Cartridge
Cartridges come in three doses: 4, 8, and 12-unit doses. All color coded.
Controller
Inpen connects to a mobile app and displays dosage information directly on a smart mobile device.
Cartridge
InPen is compatible with Humalog, Novolog, and Fiasp U-100 3.0 mL insulin cartridges.
Sensor
Sensor is inserted underneath the skin, either on the abdomen or arm. InPen is compatible with the Medtronic Guardian Connect sensor (left) or the Dexcom G6 sensor (right).
Device Details
Overview
Nothing on the body when not in use. Visible when dosing.
Discreet and modern option for people using multiple daily injections.
Affordability and Access
$$$$
Widely covered. Price range; 0-$99/month, depending on insurance coverage. $35/month for medicare and commercial insurance plans.
$$$$
Widely covered. InPen is covered by many insurance companies, typically users pay $50-$60 out-of-pocket copays for the one-year device. Prices range from $0- $549. For those without any insurance coverage, the pen's full price is $549.
Data Monitoring Options
No Options
Yes
Data can be easily shared with a healthcare provider or family members directly through the InPen app.
Data View Options
No Options
Yes
Data can be viewed on the InPen mobile app with dosage recommendations, glucose readings, and glucose trends.
Duration and Storage
10 Days
Open cartridges last up to 10 days. Sealed cartridges may be stored in a refrigerator at 36°F - 46°F until the expiration date.
12-month pen 7-day sensor
Sensor lasts for 7 days, insulin pen lasts for up to 12 months with refillable cartridges, transmitter is rechargeable. Sensor can be stored between 36°F - 86°F and pens can be kept at room temperature.
Vision / Auditory / Dexterity
NO text to speech
NO vibration alerts
LITTLE dexterity needed
NO text to speech
NO vibration alerts
A LOT of dexterity needed
Patient Considerations
Active Lifestyle
Body free of devices. Does not remain attached to the body.
Light on body. Pens are easy to use and do not remain attached to the body, sensor is waterproof.
Avoiding Highs and Lows
Very short-acting. Absorbs quickly through the lungs to correct high blood sugar but requires attention to prevent lows.
Limited customizability. System integrates the Guardian Connect CGM for high or low alerts but requires manual dose adjustment and limits the ability to adjust insulin levels throughout the day.
Comfort
Many components. Have to carry multiple cartridges that can be bulky.
Many components. Have to carry InPen and pen needles. CGM is attached to the body and requires more tape than other sensors.
Easy Insulin Dosing
Less precise but easy dosing. Dosing may be less precise due to the inhaled method of dosing, but color-coded cartridges make dosing easier. Dosing can also be done based on small, medium, or large meals and can be administered 1-2 hours post meals.
Dosing recommendations. Displays dosing recommendations and reminders for long-acting insulin.
Easy to Use
Simple design. Whistle-like device for inhaling insulin.
Simple design. Replaces regular insulin pen. No additional devices to add on.
Fewer Fingersticks
Frequent finger-sticks are required.
2 daily finger-sticks are needed to calibrate the sensor.
Privacy
Hideable. Small, discreet, and portable device that's not as noticeable as injections.
Hideable. Pens are portable but visible when in use. Frequent injections are unavoidable. View recommendations and data on a smartphone.