Medtronic Simplera Sync
Medtronic InPen
Summary
This is a disposable, all-in-one CGM sensor integrated with Medtronic’s pump systems (e.g., MiniMed 780G). Typical wear time is 6 days, plus a 24-hour “grace period.” No routine fingersticks are required when the device is in closed-loop/SmartGuard mode.
FDA approved for ages 7+ on the back of the upper arm
MARD of ~9%
The InPen system enhances management with multiple daily injections because it tracks data in real-time and offers personalized dosing recommendations. This system combines the Guardian Connect CGM with smart insulin pens for more time in range.
Components
Sensor
Sensor uses a thin, flexible filament beneath the skin to continuously measure glucose every 5 minutes. Simple, one-step applicator makes insertion fast and easy.
Controller
Inpen connects to a mobile app and displays dosage information directly on a smart mobile device.
Cartridge
InPen is compatible with Humalog, Novolog, and Fiasp U-100 3.0 mL insulin cartridges.
Sensor
Sensor is inserted underneath the skin, either on the abdomen or arm. InPen is compatible with the Medtronic Guardian Connect sensor (left) or the Dexcom G6 sensor (right).
Device Details
Overview
Disposable, all-in-one CGM sensor integrated with Medtronic’s pump systems
Discreet and modern option for people using multiple daily injections.
Affordability and Access
$$$$
Coverage depends on region and insurance; supplied via DME or specialty pharmacy.
$$$$
Widely covered. InPen is covered by many insurance companies, typically users pay $50-$60 out-of-pocket copays for the one-year device. Prices range from $0- $549. For those without any insurance coverage, the pen's full price is $549.
Data Monitoring Options
Yes
Data streams directly to the pump; users and clinicians can view trends and logs via Medtronic’s platforms.
Yes
Data can be easily shared with a healthcare provider or family members directly through the InPen app.
Data View Options
Yes
Data view directly on your connected pump or smart device.
Yes
Data can be viewed on the InPen mobile app with dosage recommendations, glucose readings, and glucose trends.
Duration and Storage
6 Days
Sensors last 6 days, with a 24-hour grace period, and need about 2 hours to warm up. They work between 41°F – 104°F and should be stored between 36°F – 86°F. They are usually shipped in 1–3 month supplies, which is about 5–15 sensors at a time.
12-month pen 7-day sensor
Sensor lasts for 7 days, insulin pen lasts for up to 12 months with refillable cartridges, transmitter is rechargeable. Sensor can be stored between 36°F - 86°F and pens can be kept at room temperature.
Vision / Auditory / Dexterity
YES text to speech
YES vibration alerts
Multiple sound sources
Moderate dexterity needed
NO text to speech
NO vibration alerts
A LOT of dexterity needed
Patient Considerations
Active Lifestyle
Compact and integrated. Reducing bulk; compatibility with daily activities depends on the adhesive and body movement. Water-resistant up to 8 feet (2.4 m) for 30 minutes.
Light on body. Pens are easy to use and do not remain attached to the body, sensor is waterproof.
Avoiding Highs and Lows
SmartGuard closed-loop. Pump adjustments use sensor data continuously to reduce highs and lows.
Limited customizability. System integrates the Guardian Connect CGM for high or low alerts but requires manual dose adjustment and limits the ability to adjust insulin levels throughout the day.
Comfort
Low profile. No overtape needed and one-hand insertion.
Many components. Have to carry InPen and pen needles. CGM is attached to the body and requires more tape than other sensors.
Easy Insulin Dosing
SmartGuard technology. When paired with the MiniMed 780G, it automatically adjusts basal and gives correction boluses based on sensor readings. In manual mode, glucose values can guide dosing decisions, but fingersticks are required for confirmation.
Dosing recommendations. Displays dosing recommendations and reminders for long-acting insulin.
Easy to Use
All-in-one. Eliminates the need for a separate transmitter, simplifying sensor changes (although more frequent due to the 6-day wear).
Simple design. Replaces regular insulin pen. No additional devices to add on.
Fewer Fingersticks
Calibration is optional. Perfect if you like having that choice.
2 daily finger-sticks are needed to calibrate the sensor.
Privacy
Small and integrated, but visible on the back of the arm. No separate transmitter reduces the number of visible parts. Alerts and alarms can be adjusted for discretion.
Hideable. Pens are portable but visible when in use. Frequent injections are unavoidable. View recommendations and data on a smartphone.