Medtronic Simplera Sync
Afrezza
Summary
This is a disposable, all-in-one CGM sensor integrated with Medtronic’s pump systems (e.g., MiniMed 780G). Typical wear time is 6 days, plus a 24-hour “grace period.” No routine fingersticks are required when the device is in closed-loop/SmartGuard mode.
FDA approved for ages 7+ on the back of the upper arm
MARD of ~9%
Inhalable regular human insulin. Cartridges come in three doses: 4, 8, and 12-unit doses.
Components
Sensor
Sensor uses a thin, flexible filament beneath the skin to continuously measure glucose every 5 minutes. Simple, one-step applicator makes insertion fast and easy.
Inhaler
Small refillable inhaler contains a compartment for powdered insulin containing cartridges.
Cartridge
Cartridges come in three doses: 4, 8, and 12-unit doses. All color coded.
Device Details
Overview
Disposable, all-in-one CGM sensor integrated with Medtronic’s pump systems
Nothing on the body when not in use. Visible when dosing.
Affordability and Access
$$$$
Coverage depends on region and insurance; supplied via DME or specialty pharmacy.
$$$$
Widely covered. Price range; 0-$99/month, depending on insurance coverage. $35/month for medicare and commercial insurance plans.
Data Monitoring Options
Yes
Data streams directly to the pump; users and clinicians can view trends and logs via Medtronic’s platforms.
No Options
Data View Options
Yes
Data view directly on your connected pump or smart device.
No Options
Duration and Storage
6 Days
Sensors last 6 days, with a 24-hour grace period, and need about 2 hours to warm up. They work between 41°F – 104°F and should be stored between 36°F – 86°F. They are usually shipped in 1–3 month supplies, which is about 5–15 sensors at a time.
10 Days
Open cartridges last up to 10 days. Sealed cartridges may be stored in a refrigerator at 36°F - 46°F until the expiration date.
Vision / Auditory / Dexterity
YES text to speech
YES vibration alerts
Multiple sound sources
Moderate dexterity needed
NO text to speech
NO vibration alerts
LITTLE dexterity needed
Patient Considerations
Active Lifestyle
Compact and integrated. Reducing bulk; compatibility with daily activities depends on the adhesive and body movement. Water-resistant up to 8 feet (2.4 m) for 30 minutes.
Body free of devices. Does not remain attached to the body.
Avoiding Highs and Lows
SmartGuard closed-loop. Pump adjustments use sensor data continuously to reduce highs and lows.
Very short-acting. Absorbs quickly through the lungs to correct high blood sugar but requires attention to prevent lows.
Comfort
Low profile. No overtape needed and one-hand insertion.
Many components. Have to carry multiple cartridges that can be bulky.
Easy Insulin Dosing
SmartGuard technology. When paired with the MiniMed 780G, it automatically adjusts basal and gives correction boluses based on sensor readings. In manual mode, glucose values can guide dosing decisions, but fingersticks are required for confirmation.
Less precise but easy dosing. Dosing may be less precise due to the inhaled method of dosing, but color-coded cartridges make dosing easier. Dosing can also be done based on small, medium, or large meals and can be administered 1-2 hours post meals.
Easy to Use
All-in-one. Eliminates the need for a separate transmitter, simplifying sensor changes (although more frequent due to the 6-day wear).
Simple design. Whistle-like device for inhaling insulin.
Fewer Fingersticks
Calibration is optional. Perfect if you like having that choice.
Frequent finger-sticks are required.
Privacy
Small and integrated, but visible on the back of the arm. No separate transmitter reduces the number of visible parts. Alerts and alarms can be adjusted for discretion.
Hideable. Small, discreet, and portable device that's not as noticeable as injections.